Growth Factors Found in Platelets "Initiate the Healing Process"

Platelet Gel Contains...

 

1.  Leukocytes   Concentrated 4 to 7 X's baseline levels

• Macrophage and Anti-Bacterial effects
  
  
• Fight off infection
  
  
  • We are all aware of the costs involved with treating acute and chronic wound infections
    
    
  • May include tens of thousands of dollars
    
    
  • Chronic wound treatment costs are even higher
    
    
  • Consider Hyperbaric Treatment of Chronic Wounds
    
    

2.  Platelets   Concentrated to 4 to 7 X's baseline levels

• "Primary Role"  >  very well known  >  HEMOSTASIS
  
  
  • Coagulate the Blood, & Prevent Blood Loss
    
    
  • Slightly (-) charge, same as vascular endothelium
    
    
  • Tissue Injury occurs, become positively (+) charged
    
    
  • Three "A's" > Adhesion, Aggregation, Agglutination
    
    
  • "come together, stick to each other, & form a plug"
    
    
• "Secondary Role"   >  GROWTH FACTOR RELEASE
  
  

3.  Growth Factors "Initiate the Healing Process"

• Platelets contain "Alpha" & "Dense" Granules
  
  
• Alpha Granules house BioActive Proteins, (Cytokines) or Growth Factors
  
  
• Responsible for Tissue & Bone Repair & Regeneration
  
  
• We concentrate Growth Factors 10 to 25 times Baseline Levels
  
  
• When Gel is applied, Calcium & Thrombin are then introduced
  
  
• Growth Factors are activated & released into the surrounding tissue
  
  
• When concentrated, these Growth Factors have been shown to Enhance & Accelerate Tissue & Bone Repair and Regeneration
  
  
• "Dense Granules" house
  
  
  • Ionized Calcium
    
    
  • Epinephrine
    
    
  • Histamine
    
    
  • Serotonin
    
    
  • ADP

 

PDGF > Platelet Derived Growth Factor

• "Initiator Protein" begins wound healing process
  
  
  • Responsible for...
    
    
    • Angiogenesis: New Blood Vessel Growth
      
      
    • Mitogenesis: Cell Replication
      
      
    • Macrophage Activation
      
      
    • Recruitment of Secondary Growth Factors
      
      

"Release Rate of PDGF" from Activated Platelets

RE Marx, DDS. Platelet-Rich Plasma (PRP): What is PRP and What is Not PRP. Implant Dentistry, Vol 10 (4), 2001: 225-8

Secondary Growth Factors

• TGF > Transforming Growth Factor
  
  
  • Responsible for...
    
    
    • Osteogenesis in Bone
      
      
    • Collagen and Cartilage Matrix
      
      
    • BMP - Bone Morphogenic Protein activation
      
      
• EGF > Epidermal Growth Factor
  
  
  • Responsible for...
    
    
    • Epithelial Development
      
      
    • Continued Angiogenesis
      
      
• IGF > Insulin Growth Factor
  
  
  • Responsible for...
    
    
    • Osteoblast differentiation and proliferation
      
      
• FGF > Fibroblast Growth factor